UC Logo
Laboratory of Developmental and Regenerative Biology
Publications, Reviews and Book Chapters

Lee-Liu, D., Sun, L., Dovichi, N. and Larraín, J. (2018) Quantitative proteomics after spinal cord injury in a regenerative and a non-regenerative stage in Xenopus laevis. Molecular and Cellular Proteomics. 17, 592-606 [View]

Edwards-Faret, G., Cebrián-Silla, A., Méndez-Olivos, E.E., González, K., García-Verdugo, J.M. and Larraín, J. (2018) Cellular composition and organization of the spinal cord central canal during metamorphosis of the frog Xenopus laevis. J. Comparative Neurology. 526: 1712-1732 [View]

Bermedo-García, F., Ojeda, J., Méndez-Olivos, E.E., Marcellini, S. Larraín, J. and Henríquez, J.P. (2018) The neuromuscular junction of Xenopus tadpoles: revisiting a classical model of early synaptogenesis and regeneration. Mechanism of Development. (in press)

González-Itier, S., Contreras, E.G., Larraín, J., Glavic, A., and Faunes, F. (2018) A role for Lin28 in growth and metamorphosis in Drosophila melanogaster. Mechanism of Development. (in press)


Lee-Liu, D., Méndez-Olivos, E.E., Muñoz, R. and Larraín, J. (2017) The African Clawed frog Xenops laevis: a model organism to study regeneration of the Central Nervous System. Neurosci Lett. 652, 82-93 [View]

Edwards-Faret, G., Muñoz, R., Méndez-Olivos, E., Lee-Liu, D., Tapia, V.S. and Larraín, J. (2017) Spinal cord regeneration in Xenopus laevis. Nature Protocols. 12, 372-389 [Accepted Manuscript] [View]

Tapia, V.S., Herrera-Rojas, M. and Larrain, J. (2017) JAK-STAT pathway activation in response to spinal cord injury in regenerative and non-regenerative stages of Xenopus laevis. Regeneration. 4, 21-35 (with Cover) [Accepted Manuscript] [View]

Faunes, F., Guzmán-Gundermann, D., Muñoz, R., Bruno, R. and Larraín, J. (2017) “The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone homeostasis” Dev. Biol. 425, 142-151 [Accepted Manuscript] [View]

Méndez-Olivos, E., Muñoz, R. and Larraín, J. (2017) Spinal cord cells from pre-metamorphic stages differentiate into neurons and promote axon growth and regeneration after transplantation into the injured spinal cord of non-regenerative Xenopus laevis froglets. Frontiers Cellular Neuroscience. 11: 398 [View]


Riadi, G., Ossandón, F., Larraín, J. and Melo, F. (2016) Towards the bridging of molecular genetics data across Xenopus species. BMC Genomics. 17, 161 [View]

Faunes, F. and Larraín, J. (2016) “A conserved program of heterochronic genes and hormones regulate stem cells during developmental transitions” Dev. Biol. 416, 3-17 [View]


Muñoz R, Edwards-Faret G, Moreno M, Zuñiga N, Cline H, Larraín J.  Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells. Dev Biol. 408, 229-243 [View]


Astudillo P, Carrasco H, Larraín J. Syndecan-4 inhibits Wnt/β-catenin signaling through regulation of Low-Density-Lipoprotein receptor-related protein (LRP6) and R-Spondin 3The International Journal of Biochemistry & Cell Biology. 46:103-112 (2014). PMID: 24275095 [View]

Astudillo P, Larraín J. Wnt signaling and cell-matrix adhesion. Current Molecular Medicine. 14(2):209-220 (2014). PMID: 24467207. doi: 10.2174/1566524014666140128105352 [Accepted Manuscript] [View]

Lee-Liu D, Moreno M, Almonacid LI, Tapia VS, Muñoz R, von Marées J, Gaete M, Melo F, Larraín J. Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages. Neural Dev. 2014 May 22;9:12. doi: 10.1186/1749-8104-9-12. [View]


Escobedo N, Contreras O, Muñoz R, Farías M, Carrasco H, Hill C, Tran U, Pryor SE, Wessely O, Copp AJ, Larraín J. Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Development. 140(14): 3008-3017 (2013). PMID: 23760952 [View] 

Lee-Liu D, Edwards-Faret G, Tapia V, Larraín J. Spinal Cord Regeneration: Lessons for Mammals from Non-Mammalian Vertebrates. Genesis. 51(8): 529-544 (2013). PMID: 23760835 [View]


Gaete M, Muñoz R, Sánchez N, Tampe R, Moreno M, Contreras E, Lee-Liu D, Larraín J. Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2 positive cells. Neural Development. 7: 13. (2012). PMID: 22537391 [View]

Faunes F, Almonacid LI, Melo F, Larrain J. Characterization of small RNAs in X. tropicalis gastrulae. Genesis. 50(7): 572-583 (2012). PMID: 22566284 [View]


Faunes F, Sánchez N, Moreno M, Olivares G, Lee-Liu D, Almonacid L, Slater A, Norambuena T, Taft R, Mattick J, Melo F, Larraín J. Regulated expression of transposable elements in neural tissues during Xenopus development. PLoS One. 6, e22569 (2011). PMID: 21818339 [View]

Palma V, Carrasco H, Reinchisi G, Olivares G, Faunes F, Larraín J. SHh activity and localization is regulated by perlecan. Biological Research. 44(1):63-67 (2011). PMID: 21720682 [View]

Faunes F, Lee-Liu D, Larraín J. Expression of DNA transposable elements during nervous system development: A discussion about its possible functions. Mobile Genetic Elements. 1(4): 296-300 (2011). PMID: 2254524 [View]


Carvallo L, Muñoz R, Bustos F, Escobedo N, Carrasco H, Olivares G, Larraín J. Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4. Journal of Biological Chemistry. 285(38): 29546-29555 (2010). PMID: 20639201 [View]


Contreras EG, Gaete M, Sánchez N, Carrasco H, Larraín J. Early requirement of Hyaluronan synthase activity for tail regeneration in Xenopus tadpoles. Development. 136: 2987-2996 (2009). PMID: 19666825 [View] 

Faunes F, Sánchez N, Castellanos J, Vergara IA, Melo F, Larraín J. Identification of novel transcripts with differential dorso-ventral expression in Xenopus gastrula using serial analysis of gene expression. Genome Biology. 10(2): R15 (2009). PMID: 19210784 [View] 

Olivares GH, Carrasco H, Aroca F, Carvallo L, Segovia F, Larraín J. Syndecan-1 regulates BMP signaling and dorso-ventral patterning during early Xenopus development Syndecan-1 regulates BMP signaling and dorso-ventral patterning during early Xenopus development. Developmental Biology. 329: 338-349 (2009). PMID: 19303002 [View]


Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyama S, Larraín J, Holt MR, Parsons M, Mayor R. Directional migration of neural crest cell in vivo is regulated by syndecan-4 dependent Rac1 and non-canonical Wnt signalling-dependent RhoA. Development. 135: 1771-1780 (2008). PMID: 18403410 [View]


Muñoz R, Moreno M, Oliva C, Orbenes C, Larraín J. Syndecan-4 regulates non-canonical Wnt signaling and is essential for convergent and extension movements in Xenopus embryos. Nature Cell Biology. 8: 492-500 (2006). PMID: 16604063 [View]

Muñoz R, Larraín J. xSyndecan-4 regulates gastrulation and neural tube closure in Xenopus embryos. ScientificWorldJournal. 6: 1298-1301 (2006). PMID: 17041718


Moreno M, Muñoz R, Aroca F, Labarca M, Brandan E, Larraín J. Biglycan is a new extracellular component of the Chordin-BMP4 signalling pathway. EMBO Journal. 24: 1397-1405 (2005). PMID: 15775969 [View]

Carrasco H, Olivares GH, Faunes F, Oliva C, Larraín J. Heparan sulfate proteoglycans exert positive and negative effects in Shh activity. Journal of Cellular Biochemistry. 96(4): 831-838 (2005). PMID: 16149075 [View]

Publications Dr. Larraín, 2005-1994 (Click to view complete list)

Oelgeschläger M, Reversade B, Larraín J, Little S, Mullins MC, De Robertis EM. The pro-BMP activity of Twisted gastrulation is independent of BMP binding.Development. 130: 4047-4056 (2003). PMID: 12874126. [View]

Larraín J, Brown C, De Robertis EM. Integrin-α3 mediates binding of Chordin to the cell surface and promotes its endocytosis. EMBO Reports. 4: 813-818 (2003). PMID: 12897802. [View]

Garcia-Abreu J, Coffinier C, Larraín J, Oelgeschlager M, De Robertis EM. Chordin-like CR domains and the regulation of evolutionary conserved extracellular signaling systems. Gene. 287: 39-47 (2002). PMID: 11992721. [View]

Coffinier C, Tran U, Larraín J, De Robertis EM. Neuralin-1 is a novel Chordin-related molecule expresses in the mouse neural plate. Mechanism of Development. 100: 119-122 (2001). PMID: 11118896. [View]

Riquelme C, Larraín J, Schonherr E, Henriquez JP, Kresse H, Brandan E. Antisense inhibition of decorin in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation. Journal of Biological Chemistry. 276: 3589-3596 (2001). PMID: 11071883. [View]

De Robertis EM, Wessely O, Oelgeschlager M, Brizuela B, Pera E, Larraín J, Abreu J, Bachiller D. Molecular mechanism of cell-cell signalling by Spemann’s organizer. International Journal of Developmental Biology. 45: 189-197 (2001). PMID: 11291846. [View]

Larraín J, Oelgeschlager M, Keptura NI, Reversade B, Zakin L, De Robertis  EM. Proteolysis of Chordin as a switch for the dual activities of Twisted gastrulationon BMP. Development. 128: 4439-4447 (2001). PMID: 11714670. [View]

Larraín J, Bachiller D, Lu B, Agius E, Piccolo S, De Robertis EM. BMP-binding modules in chordin: a model for signalling regulation in the extracellular space.Development. 127: 821-830 (2000).  PMID: 10648240. [View]

Oelgeschlager M, Larraín J, Geissert D, De Robertis EM. The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.Nature. 405: 757-763 (2000). PMID: 10866189. [View]

De Robertis EM, Larraín J, Oelgeschlager M, Wessely O. The establishment of Spemann’s organizer and patterning of the vertebrate embryo. Nature Review Genetics. 1: 171-181 (2000). PMID: 11252746. [View]

Brandan E, Larraín J. Heparan Sulfate Proteoglycans during terminal skeletal muscle differentiation: possible functions and regulation of their expression.Basic and Applied Myology. 8: 107-114 (1998). [View]

Larraín J, Carey DJ, Brandan E. Syndecan-1 expression inhibits myoblast differentiation through a basic fibroblast growth factor-dependent mechanism.Journal of Biological Chemistry. 273: 32288-32296 (1998). PMID: 9822708 [View]

Larraín J, Cizmeci-Smith G, Troncoso V, Stahl RC, Carey DJ, Brandan E. Syndecan-1 expression is down-regulated during myoblast terminal differentiation. Modulation by growth factors and retinoic acid. Journal of Biological Chemistry. 272: 18418-18424  (1997). PMID: 9218485. [View]

Larraín J, Alvarez J, Hassell JR, Brandan E. Expression of perlecan, a proteoglycan that binds myogenic inhibitory basic fibroblast growth factor, is down regulated during skeletal muscle differentiation. Experimental Cell Research 234: 405-412 (1997). PMID: 9260911. [View]

Brandan E, Carey DJ, Larraín J, Melo F, Campos A. Synthesis and processing of glypican during differentiation of skeletal muscle cells. European Journal of Cell Biology. 71: 170-176 (1996). PMID: 8905294

Urzua U, Larrondo L, Lobos S, Larraín J, Vicuña R. Oxidation reactions catalyzed by manganese peroxidase isoenzymes from Ceriporiopsis subvermispora.FEBS Letters. 371: 132-136 (1995). PMID: 7672112 [View]

Lobos S, Larraín J, Salas L, Cullen D, Vicuña R. Isoenzymes of manganese-dependent peroxidase and laccase produced by the lignin-degrading basidiomycete Ceriporiopsis subvermispora. Microbiology. 140: 2691-2698 (1994). PMID: PMID: 8000540 [View]

Salas C, Lobos S, Larraín J, Salas L, Cullen D, Vicuña R. Properties of laccase isoenzymes produced by the basidiomycete Ceriporiopsis subvermispora.Biotechnology and Applied Biochemistry. 21: 323-333 (1995). PMID: 7794534 [View]

Book chapters

Moreno M, Tapia K, Larraín J. Neural regeneration in Xenopus tadpoles during metamorphosis. Xenopus development. Life Sciences Book, Wiley-Blackwell (In Press).

Lee-Liu D, Faunes F, Almonacid L, Melo F, Larraín J. (2012) Transcriptomics Using next Generation Sequencing Technologies. Methods in Molecular Biology. 917, 293-317. PMID: 22956096 [Book chapter]